Pterygotus is a genus of giant predatory eurypterid, a group of extinct aquatic arthropods. Fossils of Pterygotus have been discovered in deposits ranging in age from Late Silurian to Late Devonian, and have been referred to several different species. Fossils have been recovered from four continents; Australia, Europe, North America and South America, which indicates that Pterygotus might have had a nearly cosmopolitan (worldwide) distribution. The type species, P. anglicus, was described by Swiss naturalist Louis Agassiz in 1839. Agassiz mistakenly believed the remains were of a giant fish, with the name Pterygotus translating to "winged fish". He would only realize the mistake five years later in 1844.

Pterygotus was among the largest eurypterids. Isolated fossil remains of a large chelicera (frontal appendage) suggests that the largest known species, P. grandidentatus, reached a body length of 1.75 metres (5.7 ft). Several other species, notably P. impacatus at 1.65 metres (5.4 ft) and P. anglicus at 1.6 metres (5.2 ft) were similarly gigantic. Pterygotus was surpassed in size by other giant eurypterids. Acutiramus was able to surpass 2 metres (6.6 ft), and Jaekelopterus could reach 2.6 metres (8.5 ft). Many species were considerably smaller than the largest species, such as P. kopaninensis at 50 centimetres (20 in).

Like its close relative Jaekelopterus, Pterygotus was a large and active predator noted for its robust and enlarged cheliceral claws that would have allowed it to puncture and grasp prey and a visual acuity (clarity of vision) comparable to that of modern predatory arthropods.